Metformin and AMP Kinase Activation Increase Expression of the Sterol Transporters ABCG5/8 (ATP-Binding Cassette Transporter G5/G8) With Potential Antiatherogenic Consequences

OBJECTIVE—: The mechanisms underlying the cardiovascular benefit of the anti-diabetic drug metformin are poorly understood. Recent studies have suggested metformin may upregulate macrophage reverse cholesterol transport. The final steps of reverse cholesterol transport are mediated by the sterol tra...

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Detalles Bibliográficos
Autores principales: Molusky, Matthew M., Hsieh, Joanne, Lee, Samuel X., Ramakrishnan, Rajasekhar, Tascau, Liana, Haeusler, Rebecca A., Accili, Domenico, Tall, Alan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039406/
https://www.ncbi.nlm.nih.gov/pubmed/29853564
http://dx.doi.org/10.1161/ATVBAHA.118.311212

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039406/
https://www.ncbi.nlm.nih.gov/pubmed/29853564
http://dx.doi.org/10.1161/ATVBAHA.118.311212

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