nSMase2 (Type 2-Neutral Sphingomyelinase) Deficiency or Inhibition by GW4869 Reduces Inflammation and Atherosclerosis in Apoe(−/−) Mice

OBJECTIVE—: Atherosclerosis is a chronic multifactorial and inflammatory disease of large and medium arteries and the leading cause of cardiovascular diseases worldwide. The aim of this study was to investigate whether and how the nSMase2 (type 2-neutral sphingomyelinase), a key enzyme of sphingolip...

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Detalles Bibliográficos
Autores principales: Lallemand, Tom, Rouahi, Myriam, Swiader, Audrey, Grazide, Marie-Hélène, Geoffre, Nancy, Alayrac, Paul, Recazens, Emeline, Coste, Agnès, Salvayre, Robert, Nègre-Salvayre, Anne, Augé, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2018
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039418/
https://www.ncbi.nlm.nih.gov/pubmed/29794115
http://dx.doi.org/10.1161/ATVBAHA.118.311208

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039418/
https://www.ncbi.nlm.nih.gov/pubmed/29794115
http://dx.doi.org/10.1161/ATVBAHA.118.311208

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