Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system

Functional evaluation assays using human induced pluripotent stem cell (hiPSC)-derived neurons can predict the convulsion toxicity of new drugs and the neurological effects of antiepileptic drugs. However, differences in responsiveness depending on convulsant type and antiepileptic drugs, and an eva...

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Detalles Bibliográficos
Autores principales: Odawara, A., Matsuda, N., Ishibashi, Y., Yokoi, R., Suzuki, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039442/
https://www.ncbi.nlm.nih.gov/pubmed/29991696
http://dx.doi.org/10.1038/s41598-018-28835-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039442/
https://www.ncbi.nlm.nih.gov/pubmed/29991696
http://dx.doi.org/10.1038/s41598-018-28835-7

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