Efficient targeted integration into the bovine Rosa26 locus using TALENs

The genetic modification of cattle has many agricultural and biomedical applications. However, random integration often results in the unstable expression of transgenes and unpredictable phenotypes. Targeting genes to the “safe locus” and stably expressing foreign genes at a high level are desirable...

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Detalles Bibliográficos
Autores principales: Wang, Ming, Sun, Zhaolin, Zou, Zhiyuan, Ding, Fangrong, Li, Ling, Wang, Haiping, Zhao, Chunjiang, Li, Ning, Dai, Yunping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039519/
https://www.ncbi.nlm.nih.gov/pubmed/29991797
http://dx.doi.org/10.1038/s41598-018-28502-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039519/
https://www.ncbi.nlm.nih.gov/pubmed/29991797
http://dx.doi.org/10.1038/s41598-018-28502-x

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