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Efficient targeted integration into the bovine Rosa26 locus using TALENs
The genetic modification of cattle has many agricultural and biomedical applications. However, random integration often results in the unstable expression of transgenes and unpredictable phenotypes. Targeting genes to the “safe locus” and stably expressing foreign genes at a high level are desirable...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039519/ https://www.ncbi.nlm.nih.gov/pubmed/29991797 http://dx.doi.org/10.1038/s41598-018-28502-x |