Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators

The psoralen-related compound, 4,6,4′-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumaca...

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Detalles Bibliográficos
Autores principales: Laselva, Onofrio, Marzaro, Giovanni, Vaccarin, Christian, Lampronti, Ilaria, Tamanini, Anna, Lippi, Giuseppe, Gambari, Roberto, Cabrini, Giulio, Bear, Christine E., Chilin, Adriana, Dechecchi, Maria C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039571/
https://www.ncbi.nlm.nih.gov/pubmed/30022950
http://dx.doi.org/10.3389/fphar.2018.00719

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039571/
https://www.ncbi.nlm.nih.gov/pubmed/30022950
http://dx.doi.org/10.3389/fphar.2018.00719

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