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Molecular Mechanism of Action of Trimethylangelicin Derivatives as CFTR Modulators

The psoralen-related compound, 4,6,4′-trimethylangelicin (TMA) potentiates the cAMP/PKA-dependent activation of WT-CFTR and rescues F508del-CFTR-dependent chloride secretion in both primary and secondary airway cells homozygous for the F508del mutation. We recently demonstrated that TMA, like lumaca...

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Detalles Bibliográficos
Autores principales:	Laselva, Onofrio, Marzaro, Giovanni, Vaccarin, Christian, Lampronti, Ilaria, Tamanini, Anna, Lippi, Giuseppe, Gambari, Roberto, Cabrini, Giulio, Bear, Christine E., Chilin, Adriana, Dechecchi, Maria C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039571/ https://www.ncbi.nlm.nih.gov/pubmed/30022950 http://dx.doi.org/10.3389/fphar.2018.00719

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