Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression

Angulated femurs are present prenatally both in CYP26B1 deficient humans with a reduced capacity to degrade retinoic acid (RA, the active metabolite of vitamin A), and mice overexpressing vascular endothelial growth factor a (Vegfa). Since excessive ingestion of vitamin A is known to induce spontane...

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Detalles Bibliográficos
Autores principales: Lind, Thomas, Lugano, Roberta, Gustafson, Ann-Marie, Norgård, Maria, van Haeringen, Arie, Dimberg, Anna, Melhus, Håkan, Robertson, Stephen P., Andersson, Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039751/
https://www.ncbi.nlm.nih.gov/pubmed/30003121
http://dx.doi.org/10.1016/j.bonr.2018.06.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039751/
https://www.ncbi.nlm.nih.gov/pubmed/30003121
http://dx.doi.org/10.1016/j.bonr.2018.06.006

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