Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir

BACKGROUND: RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies to date have focused on molecular clones with ideal target site recognition and...

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Detalles Bibliográficos
Autores principales: Roychoudhury, Pavitra, De Silva Feelixge, Harshana, Reeves, Daniel, Mayer, Bryan T., Stone, Daniel, Schiffer, Joshua T., Jerome, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040082/
https://www.ncbi.nlm.nih.gov/pubmed/29996827
http://dx.doi.org/10.1186/s12915-018-0544-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040082/
https://www.ncbi.nlm.nih.gov/pubmed/29996827
http://dx.doi.org/10.1186/s12915-018-0544-1

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