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Viral diversity is an obligate consideration in CRISPR/Cas9 designs for targeting the HIV reservoir
BACKGROUND: RNA-guided CRISPR/Cas9 systems can be designed to mutate or excise the integrated HIV genome from latently infected cells and have therefore been proposed as a curative approach for HIV. However, most studies to date have focused on molecular clones with ideal target site recognition and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040082/ https://www.ncbi.nlm.nih.gov/pubmed/29996827 http://dx.doi.org/10.1186/s12915-018-0544-1 |