The phosphoglycerate kinase 1 variants found in carcinoma cells display different catalytic activity and conformational stability compared to the native enzyme

Cancer cells are able to survive in difficult conditions, reprogramming their metabolism according to their requirements. Under hypoxic conditions they shift from oxidative phosphorylation to aerobic glycolysis, a behavior known as Warburg effect. In the last years, glycolytic enzymes have been iden...

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Detalles Bibliográficos
Autores principales: Fiorillo, Annarita, Petrosino, Maria, Ilari, Andrea, Pasquo, Alessandra, Cipollone, Alessandra, Maggi, Maristella, Chiaraluce, Roberta, Consalvi, Valerio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040698/
https://www.ncbi.nlm.nih.gov/pubmed/29995887
http://dx.doi.org/10.1371/journal.pone.0199191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040698/
https://www.ncbi.nlm.nih.gov/pubmed/29995887
http://dx.doi.org/10.1371/journal.pone.0199191

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