A speed–fidelity trade-off determines the mutation rate and virulence of an RNA virus

Mutation rates can evolve through genetic drift, indirect selection due to genetic hitchhiking, or direct selection on the physicochemical cost of high fidelity. However, for many systems, it has been difficult to disentangle the relative impact of these forces empirically. In RNA viruses, an observ...

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Detalles Bibliográficos
Autores principales: Fitzsimmons, William J., Woods, Robert J., McCrone, John T., Woodman, Andrew, Arnold, Jamie J., Yennawar, Madhumita, Evans, Richard, Cameron, Craig E., Lauring, Adam S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040757/
https://www.ncbi.nlm.nih.gov/pubmed/29953453
http://dx.doi.org/10.1371/journal.pbio.2006459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040757/
https://www.ncbi.nlm.nih.gov/pubmed/29953453
http://dx.doi.org/10.1371/journal.pbio.2006459

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