Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells

Several studies have revealed that endosomal sorting controls the steady-state levels of Notch at the cell surface in normal cells and prevents its inappropriate activation in the absence of ligands. However, whether this highly dynamic physiologic process can be exploited to counteract dysregulated...

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Detalles Bibliográficos
Autores principales: Pinazza, Marica, Ghisi, Margherita, Minuzzo, Sonia, Agnusdei, Valentina, Fossati, Gianluca, Ciminale, Vincenzo, Pezzè, Laura, Ciribilli, Yari, Pilotto, Giorgia, Venturoli, Carolina, Amadori, Alberto, Indraccolo, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041259/
https://www.ncbi.nlm.nih.gov/pubmed/29643474
http://dx.doi.org/10.1038/s41388-018-0234-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041259/
https://www.ncbi.nlm.nih.gov/pubmed/29643474
http://dx.doi.org/10.1038/s41388-018-0234-z

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