Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice

Cartilage loss in osteoarthritis (OA) results from altered local production of growth factors and metalloproteases (MMPs). Furin, an enzyme involved in the protein maturation of MMPs, might regulate chondrocyte function. Here, we tested the effect of furin on chondrocyte catabolism and the developme...

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Detalles Bibliográficos
Autores principales: Lin, Hilène, Hay, Eric, Latourte, Augustin, Funck-Brentano, Thomas, Bouaziz, Wafa, Ea, Hang-Korng, Khatib, Abdel-Majid, Richette, Pascal, Cohen-Solal, Martine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041273/
https://www.ncbi.nlm.nih.gov/pubmed/29992982
http://dx.doi.org/10.1038/s41598-018-28713-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041273/
https://www.ncbi.nlm.nih.gov/pubmed/29992982
http://dx.doi.org/10.1038/s41598-018-28713-2

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