Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation

HIV-1 protease (PR) is a homodimeric enzyme that is autocatalytically cleaved from the Gag-Pol precursor. Known PR inhibitors bind the mature enzyme several orders of magnitude more strongly than the PR precursor. Inhibition of PR at the precursor level, however, may stop the process at its rate-lim...

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Detalles Bibliográficos
Autores principales: Humpolíčková, Jana, Weber, Jan, Starková, Jana, Mašínová, Eva, Günterová, Jana, Flaisigová, Iva, Konvalinka, Jan, Majerová, Taťána
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041310/
https://www.ncbi.nlm.nih.gov/pubmed/29992979
http://dx.doi.org/10.1038/s41598-018-28638-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041310/
https://www.ncbi.nlm.nih.gov/pubmed/29992979
http://dx.doi.org/10.1038/s41598-018-28638-w

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