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Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis

Myosin X (Myo10), an actin-associated molecular motor, has a clear role in filopodia induction and cell migration in vitro, but its role in vivo in mammals is not well understood. Here, we investigate the role of Myo10 in melanocyte lineage and melanoma induction. We found that Myo10 knockout (Myo10...

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Detalles Bibliográficos
Autores principales: Tokuo, Hiroshi, Bhawan, Jag, Coluccio, Lynne M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041326/
https://www.ncbi.nlm.nih.gov/pubmed/29993000
http://dx.doi.org/10.1038/s41598-018-28717-y