Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Exploiting the full potential of anti-cancer drugs necessitates a detailed understanding of their cytotoxic effects. While standard omics approaches are limited to cell population averages, emerging single cell techniques currently lack throughput and are not applicable for compound screens. Here, w...

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Detalles Bibliográficos
Autores principales: Michelena, Jone, Lezaja, Aleksandra, Teloni, Federico, Schmid, Thomas, Imhof, Ralph, Altmeyer, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041334/
https://www.ncbi.nlm.nih.gov/pubmed/29992957
http://dx.doi.org/10.1038/s41467-018-05031-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041334/
https://www.ncbi.nlm.nih.gov/pubmed/29992957
http://dx.doi.org/10.1038/s41467-018-05031-9

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