Immunosuppressant drug tacrolimus induced mitochondrial nephrotoxicity, modified PCNA and Bcl-2 expression attenuated by Ocimum basilicum L. in CD1 mice

Tacrolimus (TAC) is used sporadically as an immunosuppressive agent for organ transplantation, but its clinical used is limited due to its marked nephrotoxicity. Ocimum basilicum L. (Lamiaceae) (OB) had been shown to possess antioxidant, anti-inflammatory and nephroprotective activity, and effective...

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Detalles Bibliográficos
Autores principales: Oyouni, Atif Abdulwahab A., Saggu, Shalini, Tousson, Ehab, Rehman, Hasibur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041355/
https://www.ncbi.nlm.nih.gov/pubmed/30003047
http://dx.doi.org/10.1016/j.toxrep.2018.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041355/
https://www.ncbi.nlm.nih.gov/pubmed/30003047
http://dx.doi.org/10.1016/j.toxrep.2018.06.003

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