Effects of RANKL Knockdown by Virus-like Particle-Mediated RNAi in a Rat Model of Osteoporosis

Rebalancing of the RANKL/OPG system seems to be an effective treatment strategy in postmenopausal osteoporosis. Here, we evaluate the knockdown of RANKL by in-vivo-delivered siRNA in a rat model of osteoporosis. Virus-like-particles (VLPs) derived from polyoma JC virus were used for delivering RANKL...

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Detalles Bibliográficos
Autores principales: Hoffmann, Daniel B., Gruber, Jens, Böker, Kai O., Deppe, Delia, Sehmisch, Stephan, Schilling, Arndt F., Lemus-Diaz, Nicolas, Komrakova, Marina, Schneider, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041464/
https://www.ncbi.nlm.nih.gov/pubmed/30195781
http://dx.doi.org/10.1016/j.omtn.2018.06.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041464/
https://www.ncbi.nlm.nih.gov/pubmed/30195781
http://dx.doi.org/10.1016/j.omtn.2018.06.001

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