A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass

Leptin expression decreases after fat loss and is increased when obesity develops, and its proper quantitative regulation is essential for the homeostatic control of fat mass. We previously reported that a distant leptin enhancer 1 (LE1), 16 kb upstream from the transcription start site (TSS), confe...

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Detalles Bibliográficos
Autores principales: Zhang, Yinxin, Dallner, Olof Stefan, Nakadai, Tomoyoshi, Fayzikhodjaeva, Gulya, Lu, Yi-Hsueh, Lazar, Mitchell A., Roeder, Robert G., Friedman, Jeffrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042069/
https://www.ncbi.nlm.nih.gov/pubmed/29891714
http://dx.doi.org/10.1073/pnas.1806366115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042069/
https://www.ncbi.nlm.nih.gov/pubmed/29891714
http://dx.doi.org/10.1073/pnas.1806366115

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