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Staphylococcus aureus targets the purine salvage pathway to kill phagocytes

Staphylococcus aureus colonizes large segments of the human population and causes invasive infections due to its ability to escape phagocytic clearance. During infection, staphylococcal nuclease and adenosine synthase A convert neutrophil extracellular traps to deoxyadenosine (dAdo), which kills pha...

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Detalles Bibliográficos
Autores principales: Winstel, Volker, Missiakas, Dominique, Schneewind, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042115/
https://www.ncbi.nlm.nih.gov/pubmed/29891696
http://dx.doi.org/10.1073/pnas.1805622115