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Ikaros cooperates with Notch activation and antagonizes TGFβ signaling to promote pDC development
Plasmacytoid and conventional dendritic cells (pDCs and cDCs) arise from monocyte and dendritic progenitors (MDPs) and common dendritic progenitors (CDPs) through gene expression changes that remain partially understood. Here we show that the Ikaros transcription factor is required for DC developmen...
Autores principales: | Mastio, Jérôme, Simand, Célestine, Cova, Giovanni, Kastner, Philippe, Chan, Susan, Kirstetter, Peggy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042690/ https://www.ncbi.nlm.nih.gov/pubmed/30001316 http://dx.doi.org/10.1371/journal.pgen.1007485 |
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