MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

Major histocompatibility complex class II (MHC II) expression and turn-over are regulated via its ubiquitination by the membrane associated RING-CH 1 (MARCH1) E3 ligase. Unexpectedly, we show that MHC II ubiquitination also impacts MHC I. Lack of MARCH1 in B cells and dendritic cells (DCs) resulted...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Kayla R., Liu, Haiyin, Healey, Geraldine, Vuong, Vivian, Ishido, Satoshi, Herold, Marco J., Villadangos, Jose A., Mintern, Justine D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042767/
https://www.ncbi.nlm.nih.gov/pubmed/30001419
http://dx.doi.org/10.1371/journal.pone.0200540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042767/
https://www.ncbi.nlm.nih.gov/pubmed/30001419
http://dx.doi.org/10.1371/journal.pone.0200540

Ejemplares similares