The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L

Tumor initiating cells (TIC) represent a subset of tumor cells with increased self-renewal capability. TICs display resistance to frontline cancer treatment and retain the ability to repopulate a tumor after therapy, leading to cancer relapse. NOTCH signaling has been identified as an important driv...

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Detalles Bibliográficos
Autores principales: Guarnieri, AL, Towers, CG, Drasin, DJ, Oliphant, MUJ, Andrysik, Z, Hotz, TJ, Vartuli, RL, Linklater, ES, Pandey, A, Khanal, S, Espinosa, JM, Ford, HL
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043359/
https://www.ncbi.nlm.nih.gov/pubmed/29662198
http://dx.doi.org/10.1038/s41388-018-0239-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043359/
https://www.ncbi.nlm.nih.gov/pubmed/29662198
http://dx.doi.org/10.1038/s41388-018-0239-7

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