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Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone

ZIKV has emerged as a significant human pathogene for the severe neurological complications, including Guillain-Barré(GBS) syndrome in adults and a variety of fetal abnormalities such as microcephaly. A stable and efficient infectious clone of Brazilian ZIKV isolate is required to study pathogenesis...

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Detalles Bibliográficos
Autores principales: Zhao, Fanfan, Xu, Yongfen, Lavillette, Dimitri, Zhong, Jin, Zou, Gang, Long, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043478/
https://www.ncbi.nlm.nih.gov/pubmed/30002446
http://dx.doi.org/10.1038/s41598-018-28890-0