Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR

53BP1 performs essential functions in DNA double-strand break (DSB) repair and it was recently reported that Tudor interacting repair regulator (TIRR) negatively regulates 53BP1 during DSB repair. Here, we present the crystal structure of the 53BP1 tandem Tudor domain (TTD) in complex with TIRR. Our...

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Detalles Bibliográficos
Autores principales: Wang, Jiaxu, Yuan, Zenglin, Cui, Yaqi, Xie, Rong, Yang, Guang, Kassab, Muzaffer A., Wang, Mengxi, Ma, Yinliang, Wu, Chen, Yu, Xiaochun, Liu, Xiuhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043480/
https://www.ncbi.nlm.nih.gov/pubmed/30002377
http://dx.doi.org/10.1038/s41467-018-05174-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043480/
https://www.ncbi.nlm.nih.gov/pubmed/30002377
http://dx.doi.org/10.1038/s41467-018-05174-9

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