Effect of ABCB1 genetic polymorphisms on the transport of rivaroxaban in HEK293 recombinant cell lines

Direct oral anticoagulants (DOAC) are substrates for the ABCB1 transporter (also called P-glycoprotein), an active efflux pump. ABCB1 polymorphisms have been previously reported to influence the pharmacokinetics of several drugs such as immunosuppressants and tyrosine kinase inhibitors. Recently, in...

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Detalles Bibliográficos
Autores principales: Sennesael, Anne-Laure, Panin, Nadtha, Vancraeynest, Christelle, Pochet, Lionel, Spinewine, Anne, Haufroid, Vincent, Elens, Laure
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043481/
https://www.ncbi.nlm.nih.gov/pubmed/30002384
http://dx.doi.org/10.1038/s41598-018-28622-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043481/
https://www.ncbi.nlm.nih.gov/pubmed/30002384
http://dx.doi.org/10.1038/s41598-018-28622-4

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