Network-based approach to prediction and population-based validation of in silico drug repurposing

Here we identify hundreds of new drug-disease associations for over 900 FDA-approved drugs by quantifying the network proximity of disease genes and drug targets in the human (protein–protein) interactome. We select four network-predicted associations to test their causal relationship using large he...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Feixiong, Desai, Rishi J., Handy, Diane E., Wang, Ruisheng, Schneeweiss, Sebastian, Barabási, Albert-László, Loscalzo, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043492/
https://www.ncbi.nlm.nih.gov/pubmed/30002366
http://dx.doi.org/10.1038/s41467-018-05116-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043492/
https://www.ncbi.nlm.nih.gov/pubmed/30002366
http://dx.doi.org/10.1038/s41467-018-05116-5

Ejemplares similares