Monocarboxylate transporter-1 promotes osteoblast differentiation via suppression of p53, a negative regulator of osteoblast differentiation

Monocarboxylate transporter-1 (MCT-1) is a transmembrane transporter for monocarboxylates including lactate and pyruvate. Silencing Mct1 by its small interfering RNA (siRNA) suppressed the expression of marker genes for osteoblast differentiation, namely, Tnap, Runx2, and Sp7, induced by BMP-2 in mo...

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Detalles Bibliográficos
Autores principales: Sasa, Kiyohito, Yoshimura, Kentaro, Yamada, Atsushi, Suzuki, Dai, Miyamoto, Yoichi, Imai, Hiroko, Nagayama, Kazuhiro, Maki, Koutaro, Yamamoto, Matsuo, Kamijo, Ryutaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043614/
https://www.ncbi.nlm.nih.gov/pubmed/30002387
http://dx.doi.org/10.1038/s41598-018-28605-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043614/
https://www.ncbi.nlm.nih.gov/pubmed/30002387
http://dx.doi.org/10.1038/s41598-018-28605-5

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