Mechanically-Loaded Breast Cancer Cells Modify Osteocyte Mechanosensitivity by Secreting Factors That Increase Osteocyte Dendrite Formation and Downstream Resorption

Advanced breast cancer predominantly metastasizes to the skeleton, at which point patient prognosis significantly declines concomitant with bone loss, pain, and heightened fracture risk. Given the skeleton's sensitivity to mechanical signals, increased mechanical loading is well-documented to i...

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Detalles Bibliográficos
Autores principales: Wang, Wenbo, Sarazin, Blayne A., Kornilowicz, Gabriel, Lynch, Maureen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043807/
https://www.ncbi.nlm.nih.gov/pubmed/30034365
http://dx.doi.org/10.3389/fendo.2018.00352

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043807/
https://www.ncbi.nlm.nih.gov/pubmed/30034365
http://dx.doi.org/10.3389/fendo.2018.00352

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