Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na(+)/H(+) exchanger isoform 1 activity

BACKGROUND: Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether the chronic effects of Ang II via AT1 receptor (AT1R) would result in endoplasm...

Descripción completa

Detalles Bibliográficos
Autores principales: Cardoso, Vanessa Gerolde, Gonçalves, Guilherme Lopes, Costa-Pessoa, Juliana Martins, Thieme, Karina, Lins, Bruna Bezerra, Casare, Fernando Augusto Malavazzi, de Ponte, Mariana Charleaux, Camara, Niels Olsen Saraiva, Oliveira-Souza, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043975/
https://www.ncbi.nlm.nih.gov/pubmed/30005635
http://dx.doi.org/10.1186/s12882-018-0968-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043975/
https://www.ncbi.nlm.nih.gov/pubmed/30005635
http://dx.doi.org/10.1186/s12882-018-0968-4

Ejemplares similares