Cargando…

Angiotensin II-induced podocyte apoptosis is mediated by endoplasmic reticulum stress/PKC-δ/p38 MAPK pathway activation and trough increased Na(+)/H(+) exchanger isoform 1 activity

BACKGROUND: Angiotensin II (Ang II) contributes to the progression of renal diseases associated with proteinuria and glomerulosclerosis mainly by inducing podocyte apoptosis. In the present study, we investigated whether the chronic effects of Ang II via AT1 receptor (AT1R) would result in endoplasm...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cardoso, Vanessa Gerolde, Gonçalves, Guilherme Lopes, Costa-Pessoa, Juliana Martins, Thieme, Karina, Lins, Bruna Bezerra, Casare, Fernando Augusto Malavazzi, de Ponte, Mariana Charleaux, Camara, Niels Olsen Saraiva, Oliveira-Souza, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043975/ https://www.ncbi.nlm.nih.gov/pubmed/30005635 http://dx.doi.org/10.1186/s12882-018-0968-4

Ejemplares similares

Intracellular albumin overload elicits endoplasmic reticulum stress and PKC-delta/p38 MAPK pathway activation to induce podocyte apoptosis
por: Gonçalves, Guilherme Lopes, et al.
Publicado: (2018)

Long-Term Angiotensin II Infusion Induces Oxidative and Endoplasmic Reticulum Stress and Modulates Na(+) Transporters Through the Nephron
por: Lins, Bruna Bezerra, et al.
Publicado: (2021)

Early type 1 diabetes aggravates renal ischemia/reperfusion-induced acute kidney injury
por: de Ponte, Mariana Charleaux, et al.
Publicado: (2021)

Differential Roles of the PKC Novel Isoforms, PKCδ and PKCε, in Mouse and Human Platelets
por: Pears, Catherine J., et al.
Publicado: (2008)

Loss of S1P Lyase Expression in Human Podocytes Causes a Reduction in Nephrin Expression That Involves PKCδ Activation
por: Imeri, Faik, et al.
Publicado: (2023)

PKCα and PKCδ: Friends and Rivals
por: Black, Jennifer D., et al.
Publicado: (2022)

B7-H4 expression is upregulated by PKCδ activation and contributes to PKCδ-induced cell motility in colorectal cancer
por: Zhou, Bin, et al.
Publicado: (2022)

DNA methylation enzymes in the kidneys of male and female BTBR ob/ob mice
por: Veloso Pereira, Beatriz Maria, et al.
Publicado: (2023)

Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolysis with a Selective PKCδ Activator
por: Bessa, Cláudia, et al.
Publicado: (2023)

Hugan Qingzhi medication ameliorates free fatty acid-induced L02 hepatocyte endoplasmic reticulum stress by regulating the activation of PKC-δ
por: Yang, Miaoting, et al.
Publicado: (2020)

Single Ethanol Withdrawal Regulates Extrasynaptic δ-GABA(A) Receptors Via PKCδ Activation
por: Chen, Juan, et al.
Publicado: (2018)

PKCδ Blues for the β-Cell
por: Schmitz-Peiffer, Carsten, et al.
Publicado: (2010)

Overexpressed PKCδ Downregulates the Expression of PKCα in B16F10 Melanoma: Induction of Apoptosis by PKCδ via Ceramide Generation
por: Halder, Kuntal, et al.
Publicado: (2014)

PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 production
por: Serrero, Manutea, et al.
Publicado: (2017)

Attenuation of PKCδ enhances metabolic activity and promotes expansion of blood progenitors
por: Rao, Tata Nageswara, et al.
Publicado: (2018)

Sodium Oxalate-Induced Acute Kidney Injury Associated With Glomerular and Tubulointerstitial Damage in Rats
por: de Araújo, Larissa, et al.
Publicado: (2020)

Bryostatin-1 vs. TPPB: Dose-Dependent APP Processing and PKC-α, -δ, and -ε Isoform Activation in SH-SY5Y Neuronal Cells
por: Yi, P., et al.
Publicado: (2012)

Ischaemic preconditioning improves proteasomal activity and increases the degradation of δPKC during reperfusion
por: Churchill, Eric N., et al.
Publicado: (2010)

PKC isoforms interact with and phosphorylate DNMT1
por: Lavoie, Geneviève, et al.
Publicado: (2011)

Podocytic PKC-Alpha Is Regulated in Murine and Human Diabetes and Mediates Nephrin Endocytosis
por: Tossidou, Irini, et al.
Publicado: (2010)

PKCδ regulates the vascular biology in diabetic atherosclerosis
por: Qin, Peiliang, et al.
Publicado: (2023)

Disruption of Spectrin-Like Cytoskeleton in Differentiating Keratinocytes by PKCδ Activation Is Associated with Phosphorylated Adducin
por: Zhao, Kong-Nan, et al.
Publicado: (2011)

PKCδ deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCδ knockout mice
por: Niino, Yuko S., et al.
Publicado: (2021)

Co-ordinated activation of classical and novel PKC isoforms is required for PMA-induced mTORC1 activation
por: Liu, Mengling, et al.
Publicado: (2017)

Differential and Conditional Activation of PKC-Isoforms Dictates Cardiac Adaptation during Physiological to Pathological Hypertrophy
por: Naskar, Shaon, et al.
Publicado: (2014)

Diacylglycerol-evoked activation of PKC and PKD isoforms in regulation of glucose and lipid metabolism: a review
por: Kolczynska, Katarzyna, et al.
Publicado: (2020)

Glutathione Depletion by L-Buthionine-S,R-Sulfoximine Induces Apoptosis of Cardiomyocytes through Activation of PKC-δ
por: Kim, Young-Ae, et al.
Publicado: (2013)

PKCδ silencing alleviates saturated fatty acid induced ER stress by enhancing SERCA activity
por: Lai, Shujie, et al.
Publicado: (2017)

Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351
por: Park, Jee-Yun, et al.
Publicado: (2021)

Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism
por: Li, Mengyao, et al.
Publicado: (2015)

Control of nuclear-cytoplasmic shuttling of Ankrd54 by PKCδ
por: Samuels, Amy L, et al.
Publicado: (2017)

Role of FGFR2b expression and signaling in keratinocyte differentiation: sequential involvement of PKCδ and PKCα
por: Rosato, Benedetta, et al.
Publicado: (2018)

Spatio-Temporal Regulation of PKC Isoforms Imparts Signaling Specificity
por: Mukherjee, Arkajyoti, et al.
Publicado: (2016)

Regulation of the viability of Nf1 deficient cells by PKC isoforms
por: Zhou, Xiaodong, et al.
Publicado: (2014)

An Essential Role of the Universal Polarity Protein, aPKCλ, on the Maintenance of Podocyte Slit Diaphragms
por: Hirose, Tomonori, et al.
Publicado: (2009)

Opposed Actions of PKA Isozymes (RI and RII) and PKC Isoforms (cPKCβI and nPKCε) in Neuromuscular Developmental Synapse Elimination
por: Garcia, Neus, et al.
Publicado: (2019)

Proteasome inhibitor-induced apoptosis is mediated by positive feedback amplification of PKCδ proteolytic activation and mitochondrial translocation
por: Sun, Faneng, et al.
Publicado: (2008)

Mechanical Stress Activates Smad Pathway through PKCδ to Enhance Interleukin-11 Gene Transcription in Osteoblasts
por: Kido, Shinsuke, et al.
Publicado: (2010)

Estrogen increases ENaC activity via PKCδ signaling in renal cortical collecting duct cells
por: Yusef, Yamil R., et al.
Publicado: (2014)

PKCδ activated by c-MET enhances infiltration of human glioblastoma cells through NOTCH2 signaling
por: Hwang, Eunji, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_jp1ub4cpmucmm95866mdv6drrs