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BET inhibition in advanced cutaneous T cell lymphoma is synergistically potentiated by BCL2 inhibition or HDAC inhibition

While several systemic therapies are approved for cutaneous T cell lymphoma (CTCL), a non-Hodgkin lymphoma of skin-homing T cells that may involve lymph nodes and peripheral blood in advanced stages, relapses are common. Mutational analysis of CTCL cells has revealed frequent amplification of the MY...

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Detalles Bibliográficos
Autores principales: Kim, Sa Rang, Lewis, Julia M., Cyrenne, Benoit M., Monico, Patrick F., Mirza, Fatima N., Carlson, Kacie R., Foss, Francine M., Girardi, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044378/
https://www.ncbi.nlm.nih.gov/pubmed/30018745
http://dx.doi.org/10.18632/oncotarget.25670