Induction of innate immune memory via microRNA targeting of chromatin remodeling factors

Prolonged exposure to microbial products, e.g. lipopolysaccharide (LPS), can induce a form of innate immune memory that blunts subsequent responses to unrelated pathogens (“LPS tolerance”). Sepsis, which continues to have a high mortality rate, is a dysregulated, systemic immune response to dissemin...

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Detalles Bibliográficos
Autores principales: Seeley, John J., Baker, Rebecca, Mohamed, Ghait, Bruns, Tony, Hayden, Matthew S., Deshmukh, Sachin D., Freedberg, Daniel E., Ghosh, Sankar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044474/
https://www.ncbi.nlm.nih.gov/pubmed/29950719
http://dx.doi.org/10.1038/s41586-018-0253-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044474/
https://www.ncbi.nlm.nih.gov/pubmed/29950719
http://dx.doi.org/10.1038/s41586-018-0253-5

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