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Induction of innate immune memory via microRNA targeting of chromatin remodeling factors
Prolonged exposure to microbial products, e.g. lipopolysaccharide (LPS), can induce a form of innate immune memory that blunts subsequent responses to unrelated pathogens (“LPS tolerance”). Sepsis, which continues to have a high mortality rate, is a dysregulated, systemic immune response to dissemin...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044474/ https://www.ncbi.nlm.nih.gov/pubmed/29950719 http://dx.doi.org/10.1038/s41586-018-0253-5 |