6-(Ar)Alkylamino-Substituted Uracil Derivatives: Lipid Mimetics with Potent Activity at the Orphan G Protein-Coupled Receptor 84 (GPR84)

[Image: see text] GPR84, a G(i) protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. Recently, 6-octylaminouracil (4) has been reported to act as an agonist at GPR84. Here, we describe the synthesis...

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Detalles Bibliográficos
Autores principales: Pillaiyar, Thanigaimalai, Köse, Meryem, Namasivayam, Vigneshwaran, Sylvester, Katharina, Borges, Gleice, Thimm, Dominik, von Kügelgen, Ivar, Müller, Christa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044507/
https://www.ncbi.nlm.nih.gov/pubmed/30023867
http://dx.doi.org/10.1021/acsomega.7b02092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044507/
https://www.ncbi.nlm.nih.gov/pubmed/30023867
http://dx.doi.org/10.1021/acsomega.7b02092

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