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A dual regulation mechanism of histidine kinase CheA identified by combining network-dynamics modeling and system-level input-output data

It is challenging to decipher molecular mechanisms in biological systems from system-level input-output data, especially for complex processes that involve interactions among multiple components. We addressed this general problem for the bacterial histidine kinase CheA, the activity of which is regu...

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Detalles Bibliográficos
Autores principales: Mello, Bernardo A., Pan, Wenlin, Hazelbauer, Gerald L., Tu, Yuhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044545/
https://www.ncbi.nlm.nih.gov/pubmed/29965962
http://dx.doi.org/10.1371/journal.pcbi.1006305