Structure–Activity Relationships of Cbx7 Inhibitors, Including Selectivity Studies against Other Cbx Proteins

[Image: see text] The five human polycomb (Pc) paralog proteins, chromobox homolog (Cbx) 2/4/6/7/8, are a family of chromodomain containing methyllysine reader proteins that are canonical readers of trimethyllysine 27 on histone 3 (H3K27me3). The aberrant expression of the Cbx7 gene is implicated in...

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Detalles Bibliográficos
Autores principales: Simhadri, Chakravarthi, Gignac, Michael C., Anderson, Cameron J., Milosevich, Natalia, Dheri, Aman, Prashar, Nishant, Flemmer, Robert T., Dev, Amarjot, Henderson, Trevor G., Douglas, Sarah F., Wulff, Jeremy E., Hof, Fraser
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044621/
https://www.ncbi.nlm.nih.gov/pubmed/30023485
http://dx.doi.org/10.1021/acsomega.6b00120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044621/
https://www.ncbi.nlm.nih.gov/pubmed/30023485
http://dx.doi.org/10.1021/acsomega.6b00120

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