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Using the Variable-Nearest Neighbor Method To Identify P-Glycoprotein Substrates and Inhibitors
[Image: see text] Permeability glycoprotein (Pgp) is an essential membrane-bound transporter that efficiently extracts compounds from a cell. As such, it is a critical determinant of the pharmacokinetic properties of drugs. Multidrug resistance in cancer is often associated with overexpression of Pg...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044698/ https://www.ncbi.nlm.nih.gov/pubmed/30023496 http://dx.doi.org/10.1021/acsomega.6b00247 |