Drug-Clinical Agent Molecular Hybrid: Synthesis of Diaryl(trifluoromethyl)pyrazoles as Tubulin Targeting Anticancer Agents

[Image: see text] Twenty-three combretastatin A-4 (CA-4) analogues were synthesized by judiciously incorporating a functional N-heterocyclic motif present in Celecoxib (a marketed drug) while retaining essential pharmacophoric features of CA-4. Combretastatin-(trifluoromethyl)pyrazole hybrid analogu...

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Detalles Bibliográficos
Autores principales: Hura, Neha, Naaz, Afsana, Prassanawar, Shweta S., Guchhait, Sankar K., Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044759/
https://www.ncbi.nlm.nih.gov/pubmed/30023819
http://dx.doi.org/10.1021/acsomega.7b01784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044759/
https://www.ncbi.nlm.nih.gov/pubmed/30023819
http://dx.doi.org/10.1021/acsomega.7b01784

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