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Difatty Acyl-Conjugated Linear and Cyclic Peptides for siRNA Delivery

[Image: see text] A number of amphiphilic difatty acyl linear and cyclic R(5)K(2) peptide conjugates were synthesized by solid-phase peptide methods to enhance the interaction with the hydrophobic cellular phospholipid bilayer and to improve siRNA delivery and silencing. Binding to siRNA molecules w...

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Detalles Bibliográficos
Autores principales: Do, Hung, Sharma, Meenakshi, El-Sayed, Naglaa Salem, Mahdipoor, Parvin, Bousoik, Emira, Parang, Keykavous, Montazeri Aliabadi, Hamidreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044792/
https://www.ncbi.nlm.nih.gov/pubmed/30023535
http://dx.doi.org/10.1021/acsomega.7b00741