Role of Pseudoisocytidine Tautomerization in Triplex-Forming Oligonucleotides: In Silico and in Vitro Studies

[Image: see text] Pseudoisocytidine ((Ψ)C) is a synthetic cytidine analogue that can target DNA duplex to form parallel triplex at neutral pH. Pseudoisocytidine has mainly two tautomers, of which only one is favorable for triplex formation. In this study, we investigated the effect of sequence on (Ψ...

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Detalles Bibliográficos
Autores principales: Hartono, Yossa Dwi, Pabon-Martinez, Y. Vladimir, Uyar, Arzu, Wengel, Jesper, Lundin, Karin E., Zain, Rula, Smith, C. I. Edvard, Nilsson, Lennart, Villa, Alessandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044803/
https://www.ncbi.nlm.nih.gov/pubmed/30023656
http://dx.doi.org/10.1021/acsomega.7b00347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044803/
https://www.ncbi.nlm.nih.gov/pubmed/30023656
http://dx.doi.org/10.1021/acsomega.7b00347

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