High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody–Drug Conjugate Aggregation and Drug Release

[Image: see text] The stability of antibody–drug conjugates (ADCs) in circulation is critical for maximum efficacy and minimal toxicity. An ADC reaching the intended target intact can deliver the highest possible drug load to the tumor and reduce off-target toxicity from free drug in the blood. As s...

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Detalles Bibliográficos
Autores principales: Durbin, Kenneth R., Nottoli, M. Shannon, Catron, Nathaniel D., Richwine, Nicole, Jenkins, Gary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044903/
https://www.ncbi.nlm.nih.gov/pubmed/30023717
http://dx.doi.org/10.1021/acsomega.7b00452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044903/
https://www.ncbi.nlm.nih.gov/pubmed/30023717
http://dx.doi.org/10.1021/acsomega.7b00452

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