In Vitro Protein Stability of Two Naturally Occurring Thiopurine S-Methyltransferase Variants: Biophysical Characterization of TPMT*6 and TPMT*8

[Image: see text] Thiopurine S-methyltransferase (TPMT) is a polymorphic enzyme involved in the metabolism and inactivation of thiopurine substances administered as immunosuppressants in the treatment of malignancies and autoimmune diseases. In this study, the naturally occurring variants, TPMT*6 (Y...

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Detalles Bibliográficos
Autores principales: Wennerstrand, Patricia, Blissing, Annica, Mårtensson, Lars-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044926/
https://www.ncbi.nlm.nih.gov/pubmed/30023734
http://dx.doi.org/10.1021/acsomega.7b00801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044926/
https://www.ncbi.nlm.nih.gov/pubmed/30023734
http://dx.doi.org/10.1021/acsomega.7b00801

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