Role of Cys(I)–Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors

[Image: see text] α-Conotoxins preferentially antagonize muscle and neuronal nicotinic acetylcholine receptors (nAChRs). Native α-conotoxins have two disulfide links, C(I)–C(III) and C(II)–C(IV), and owing to the inherent properties of disulfide bonds, α-conotoxins have been systematically engineere...

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Detalles Bibliográficos
Autores principales: Tabassum, Nargis, Tae, Han-Shen, Jia, Xinying, Kaas, Quentin, Jiang, Tao, Adams, David J., Yu, Rilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044955/
https://www.ncbi.nlm.nih.gov/pubmed/30023726
http://dx.doi.org/10.1021/acsomega.7b00639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044955/
https://www.ncbi.nlm.nih.gov/pubmed/30023726
http://dx.doi.org/10.1021/acsomega.7b00639

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