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New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study
[Image: see text] Aldose reductase is the first enzyme of the polyol pathway in which glucose is converted to fructose via sorbitol. The understanding of this key enzyme is important as it has been linked to some diabetes mellitus complications. The mechanism of the enzyme was investigated using a h...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044956/ https://www.ncbi.nlm.nih.gov/pubmed/30023751 http://dx.doi.org/10.1021/acsomega.7b00815 |