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New Insights into the Catalytic Mechanism of Aldose Reductase: A QM/MM Study

[Image: see text] Aldose reductase is the first enzyme of the polyol pathway in which glucose is converted to fructose via sorbitol. The understanding of this key enzyme is important as it has been linked to some diabetes mellitus complications. The mechanism of the enzyme was investigated using a h...

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Detalles Bibliográficos
Autores principales: Dréanic, Marie-Pierre, Edge, Colin M., Tuttle, Tell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044956/
https://www.ncbi.nlm.nih.gov/pubmed/30023751
http://dx.doi.org/10.1021/acsomega.7b00815