Route to Benzimidazol-2-ones via Decarbonylative Ring Contraction of Quinoxalinediones: Application to the Synthesis of Flibanserin, A Drug for Treating Hypoactive Sexual Desire Disorder in Women and Marine Natural Product Hunanamycin Analogue

[Image: see text] A simple and practical method to access a variety of benzimidazol-2-ones is reported here. A series of N-alkyl-substituted benzimidazol-2-ones were synthesized by decarbonylative ring contraction starting from corresponding quinoxalinediones for the first time. The utility of the m...

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Detalles Bibliográficos
Autores principales: Shingare, Rahul D., Kulkarni, Akshay S., Sutar, Revannath L., Reddy, D. Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044990/
https://www.ncbi.nlm.nih.gov/pubmed/30023739
http://dx.doi.org/10.1021/acsomega.7b00819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6044990/
https://www.ncbi.nlm.nih.gov/pubmed/30023739
http://dx.doi.org/10.1021/acsomega.7b00819

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