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Small-Molecule Ligands as Potential GDNF Family Receptor Agonists

[Image: see text] To find out potential GDNF family receptor α1 (GFRα1) agonists, small molecules were built up by molecular fragments according to the structure-based drug design approach. Molecular docking was used to identify their binding modes to the biological target GFRα1 in GDNF-binding pock...

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Detalles Bibliográficos
Autores principales: Ivanova, Larisa, Tammiku-Taul, Jaana, Sidorova, Yulia, Saarma, Mart, Karelson, Mati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045390/
https://www.ncbi.nlm.nih.gov/pubmed/30023796
http://dx.doi.org/10.1021/acsomega.7b01932