Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation

[Image: see text] Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with the use of small molecules in regenerative medicine. Here, we report the design and bioefficacy of the synthetic ligand PIP-RBPJ...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Yulei, Pandian, Ganesh N., Yu, Zutao, Zou, Tingting, Li, Yue, Darokar, Jayant, Hashiya, Kaori, Bando, Toshikazu, Sugiyama, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045482/
https://www.ncbi.nlm.nih.gov/pubmed/30023873
http://dx.doi.org/10.1021/acsomega.8b00220
_version_ 1783339671261020160
author Wei, Yulei
Pandian, Ganesh N.
Yu, Zutao
Zou, Tingting
Li, Yue
Darokar, Jayant
Hashiya, Kaori
Bando, Toshikazu
Sugiyama, Hiroshi
author_facet Wei, Yulei
Pandian, Ganesh N.
Yu, Zutao
Zou, Tingting
Li, Yue
Darokar, Jayant
Hashiya, Kaori
Bando, Toshikazu
Sugiyama, Hiroshi
author_sort Wei, Yulei
collection PubMed
description [Image: see text] Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with the use of small molecules in regenerative medicine. Here, we report the design and bioefficacy of the synthetic ligand PIP-RBPJ-1, which caused promoter-specific suppression of neurogenesis-associated HES1 and its downstream genes. Furthermore, PIP-RBPJ-1 alone altered the neural-system-associated Notch-signaling factors and remarkably induced neurogenesis with an efficiency that was comparable to that of a conventional approach.
format Online
Article
Text
id pubmed-6045482
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher American Chemical Society
record_format MEDLINE/PubMed
spelling pubmed-60454822018-07-16 Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation Wei, Yulei Pandian, Ganesh N. Yu, Zutao Zou, Tingting Li, Yue Darokar, Jayant Hashiya, Kaori Bando, Toshikazu Sugiyama, Hiroshi ACS Omega [Image: see text] Synthetic DNA-binding inhibitors capable of gaining precise control over neurogenesis factors could obviate the current clinical barriers associated with the use of small molecules in regenerative medicine. Here, we report the design and bioefficacy of the synthetic ligand PIP-RBPJ-1, which caused promoter-specific suppression of neurogenesis-associated HES1 and its downstream genes. Furthermore, PIP-RBPJ-1 alone altered the neural-system-associated Notch-signaling factors and remarkably induced neurogenesis with an efficiency that was comparable to that of a conventional approach. American Chemical Society 2018-03-30 /pmc/articles/PMC6045482/ /pubmed/30023873 http://dx.doi.org/10.1021/acsomega.8b00220 Text en Copyright © 2018 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Wei, Yulei
Pandian, Ganesh N.
Yu, Zutao
Zou, Tingting
Li, Yue
Darokar, Jayant
Hashiya, Kaori
Bando, Toshikazu
Sugiyama, Hiroshi
Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title_full Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title_fullStr Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title_full_unstemmed Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title_short Synthetic DNA-Binding Inhibitor of HES1 Alters the Notch Signaling Pathway and Induces Neuronal Differentiation
title_sort synthetic dna-binding inhibitor of hes1 alters the notch signaling pathway and induces neuronal differentiation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045482/
https://www.ncbi.nlm.nih.gov/pubmed/30023873
http://dx.doi.org/10.1021/acsomega.8b00220
work_keys_str_mv AT weiyulei syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT pandianganeshn syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT yuzutao syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT zoutingting syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT liyue syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT darokarjayant syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT hashiyakaori syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT bandotoshikazu syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation
AT sugiyamahiroshi syntheticdnabindinginhibitorofhes1altersthenotchsignalingpathwayandinducesneuronaldifferentiation

Ejemplares similares